![]() ![]() Each KSD-TK component had high sensitivity, but only three had specificity ≥0.75: auditory neuropathy spectrum disorder, abnormal movements and/or tone on follow-up exam, and abnormal globus pallidus and/or subthalamic nucleus on MRI. Combining KSD-TK “definite” and “probable”, the KSD-TK has 96.6% sensitivity and 87.5% specificity. ![]() ![]() None of 6 patients with KSD-TK “not kernicterus” were clinically diagnosed with kernicterus. Of 37 patients, 29 were clinically diagnosed with kernicterus, including 14/14 with KSD-TK scored as “definite”, 14/15 “probable”, and 1/2 with “possible” kernicterus. KSD-TK results were compared to the clinical diagnoses given by a kernicterus expert (SS). Through retrospective chart review, we completed a KSD-TK for 37 patients evaluated between 20 using highest bilirubin, newborn risk factors, neonatal exam, follow-up exam, auditory testing, tooth enamel, and MRI brain results. This study aims to validate the KSD-TK by comparing it to clinical diagnoses made by the Kernicterus Clinic in the Division of Neurology. ![]() We developed a Toolkit (KSD-TK) to predict the likelihood of KSDs. Kernicterus Spectrum Disorders (KSDs) result from hyperbilirubinemia-induced brain injury. ![]()
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